|
Clinically proven
to reduce oxidative stress.
Protandim featured on
ABC's PrimeTime Live
|
|
|
|
|
|
Oxidative Stress and Aging
Age-related accrual of oxidative stress is the balance between the rate of reactive oxygen species generation and the activity of antioxidant defense enzymes, tissue antioxidant concentrations and repair processes. The free radical theory of aging, argues that oxidative damage plays a key role in degenerative senescence and aging. Mitochondrial metabolism is known to be a major source of superoxide free radical generation, as well as of the non-free radical oxidant hydrogen peroxide, contributing to oxidative stress and aging. The gradual loss of energy with age is paralleled by a decrease in number of mitochondria per cell, as well as the health and energy-producing efficiency of those remaining mitochondria. End-point measures of oxidative stress such as tissue lipid peroxidation, oxidative lesions in genomic and mitochondrial DNA and protein carbonyl formation increase with aging. The consequence of this destructive activity is an inefficient cell and a body we recognize as aged (wrinkled skin, low energy level).
About Aging
- In 2005 the older population (65+) numbered 36.3 million people in the US.
- There are more older women than men worldwide
- In 2004, the median income of older persons was $21,102 for males and $12, 080 for females
- 36.7% of older persons assessed their health as excellent or very good (compared with 66% of persons aged 18 – 64)
- Most older persons have at least one chronic health condition and many have multiple conditions
- 24% report weight that places them among the obese
- In 2003, older consumers averaged $3,899 in out-of-pocket health care expenditures, an increase of 46% since 1993 (and 12.5% of their total yearly expenditures
- Ability to perform activities (including bathing, showering, dressing, eating, getting in/out of bed, walking, using toilet) because of chronic conditions decreases with age
- 25% use the internet for email, information on and purchase of products and services, and health information
Risk Factors
- The incidence of disease is greater in older individuals who:
- Smoke
- Are overweight or obese
- Are not physically active
- Have high cholesterol
- Have high oxidative stress
- A growing body of evidence points toward oxidative stress as one of the primary determinants of progressive declines of biological functions with increasing age
Risk Reducers
- Social Activity. Those who interact with others tend to be healthier, both physically and mentally.
- Being Active
- Getting vaccinated against influenza
- Dietary Quality
- Redox systems that can regenerate antioxidants at the cellular level are of vital importance because they could protect the intracellular components from oxidant damage
The Studies
Mitochondrial aging: open questions
Beckman KB, Ames BN, Ann N Y Acad Sci. 1998; 854:118-27
Abstract: Interest in the role of mitochondria in aging has intensified in recent years. This focus on mitochondria originated in part from the free radical theory of aging, which argues that oxidative damage plays a key role in degenerative senescence. Among the numerous mechanisms known to generate oxidants, leakage of the superoxide anion and hydrogen peroxide from the mitochondrial electron transport chain are of particular interest, due to the correlation between species-specific metabolic rate
The free radical theory of aging matures
Beckman KB, Ames BN, , Physiol Rev.1998; 78(2):547-81
Abstract: The free radical theory of aging, conceived in 1956, has turned 40 and is rapidly attracting the interest of the mainstream of biological research. From its origins in radiation biology, through a decade or so of dormancy and two decades of steady phenomenological research, it has attracted an increasing number of scientis | | |
|
|
|