| |
|
Clinically proven
to reduce oxidative stress.
|
|
|
|
|
|
Oxidative Stress and Arthritis
Arthritis is actually an umbrella term used for a group of more than 100 medical conditions which affect the musculoskeletal system and specifically the joints - where two or more bones meet. Arthritis-related joint problems include pain, stiffness, inflammation and damage to joint cartilage (the tough, smooth tissue that covers the ends of the bones, enabling them to glide against one another) and surrounding structures. Oxidative stress plays a significant role in the pathogenesis of arthritis. Increased oxidative stress and a low antioxidant status in patients with rheumatoid arthritis have been reported.
About Arthritis
- An autoimmune disease. Autoimmune disorders can cause immune-responsive cells to attack the linings of the joints – resulting in arthritis.
- Studies have shown that arthritis patients are more susceptible to oxidative damage than those who do not suffer from arthritis. Significant increase in SOD is one agent that seems to be beneficial in osteoarthritis. (Evidence for Oxidative Stress in Osteoarthritis – M Maneesh)
- The leading cause of disability in the United States.
- More than 46 million adults in the US have the disease
- 50% of adults over 65 report having the disease
- Affects all race and ethnic groups
- $51 Billion in medical costs per year
- Strongly associated with major depression
Risk Factors
- Age is the biggest risk factor
- 66% of adults with Arthritis are overweight or obese
Risk Reducers
- Be Active – research has shown that physical activity delays disability
- Maintain a healthy weight. A loss of just 11 pounds can decrease the occurrence of knee osteoarthritis.
- See Your Doctor – early diagnosis and appropriate management can affect the course of arthritis
- Protect Your Joints – avoid joint injury
- Eliminate free radical damage to the joints/lower oxidative stress.
The Studies
Antioxidants and inflammatory disease: synthetic and natural antioxidants with anti-inflammatory activity
Geronikaki AA, Gavalas AM. Aristotle University of Thessaloniki, School of Pharmacy, Thessaloniki 54124, Greece. geronik@pharm.auth.gr
Abstract not available
Oxidative stress parameters in different systemic rheumatic diseases
Firuzi O, Fuksa L, Spadaro C, Bousova I, Riccieri V, Spadaro A, Petrucci R, Marrosu G, Saso L. Dipartimento di Fisiologia Umana e Farmacologia "Vittorio Erspamer", Universita di Roma "La Sapienza", Italy.
Abstract: The involvement of oxidative stress in the pathogenesis of rheumatic disorders, such as systemic sclerosis (SSc) and chronic polyarthritides, has been suggested yet not thoroughly verified experimentally. We analysed 4 plasmatic parameters of oxidative stress in patients with SSc (n = 17), psoriatic arthritis (PsA) (n = 10) and rheumatoid arthritis (RA) (n = 9) compared with healthy subjects (n = 22). The biomarkers were: total antioxidant capacity (TAC) measured by ferric reducing antioxidant power (FRAP) method, hydroperoxides determined by ferrous ion oxidation in presence of xylenol orange (FOX) method and sulfhydryl and carbonyl groups assessed by spectrophotometric assays. The results showed significantly increased hydroperoxides in SSc, PsA and RA (3.97 +/- 2.25, 4.87 +/- 2.18 and 5.13 +/- 2.36 micromol L(-1), respectively) compared with the control group (2.31 +/- 1.40 micromol L(-1); P < 0.05). Sulfhydryls were significantly lower in SSc (0.466 +/- 0.081 mmol L(-1)), PsA (0.477 +/- 0.059 mmol L(-1)) and RA (0.439 +/- 0.065 mmol L(-1)) compared with the control group (0.547 +/- 0.066 mmol L(-1); P < 0.05). TAC in all three diseases showed no difference in comparison with controls. Carbonyls were significantly higher in RA than in the control group (32.1 +/- 42 vs 2.21 +/- 1.0 nmol (mg protein)(-1); P < 0.05). The obtained data indicate augmented free radical-mediated injury in these rheumatic diseases and s | | |
|
|
|
|
|