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Clinically proven
to reduce oxidative stress.
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Oxidative Stress and Crohn’s Disease
Crohn’s disease (CD) is an inflammatory bowel disease. Crohn’s disease is an ongoing disorder that causes inflammation of the gastrointestinal (GI) tract. Crohn’s disease can affect any area of the GI tract, from the mouth to the anus, but it most commonly affects the lower part of the small intestine, called the ileum. The swelling extends deep into the lining of the affected organ. The swelling can cause pain and can make the intestines empty frequently, resulting in diarrhea. In CD, the increased production of reactive oxygen species from activated neutrophils may reduce plasma concentrations of antioxidant vitamins and result in increased oxidative stress. The decreased antioxidant defenses may be a primary phenomenon severely compromising the mucosa and therefore increasing susceptibility to oxidative tissue damage.
About Crohn’s Disease
- Commonly called Inflammatory Bowel Disease
- Affects two to four times more Caucasian whites than non-Caucasians
- Four times more likely in Jewish population
- Affects men and women equally, and children may also develop the disease
- Some genetic association appears to exist – about 20% of Crohn’s disease patients have a close family member with an inflammatory bowel disease
- Onset typically between the ages of 14 – 30
- Some research suggests that over time, if the disease is active, may increase the risk of cancer by as much as twenty times
- Arthritis affects about 25% of Crohn’s Disease sufferers
Risk Factors
- There is no known cause for Crohn’s Disease. However, studies have shown that oxidative stress and damage from free radicals has a role in the disease.
- Contributing factors have been identified as:
- Poor eating habits
- Stress
- Food allergies
- Overuse of antibiotics
- Blockage of the intestines
Risk Reducers
- Because the cause of Colitis is unknown, risk reducers are really symptom reducers/treatments, and vary from individual to individual.
- Lower oxidative stress, which reduces inflammation in the intestines and can help promote the healing of damaged tissues.
The Studies
Decreased total and corrected antioxidant capacity in patients with inflammatory bowel disease.
Koutroubakis IE, Malliaraki N, Dimoulios PD, Karmiris K, Castanas E, Kouroumalis EA. Dig Dis Sci. 2004 Sep;49(9):1433-7
Oxidative stress and depletion of antioxidants may play a key role in the pathogenesis of inflammatory bowel disease (IBD)-related intestinal damage. A new automated assay for the determination of blood total antioxidant capacity (TAC), based on the crocin bleaching method, has been used for the measurement of TAC and corrected TAC (cTAC) in patients with ulcerative colitis (UC) and Crohn's disease (CD) in comparison to healthy controls (HC). Ninety-four patients with UC, 97 patients with CD, and 72 HC were included in this study. Serum TAC was measured in all patients and controls on an Olympus AU-600 chemistry analyzer using a TAC kit. cTAC was calculated from TAC after subtraction of the interactions due to endogenous uric acid, bilirubin and albumin. Mean serum TAC as well as cTAC levels were significantly lower in both UC and CD patients compared with HC (P < 0.0001). Patients with active UC had no different TAC and cTAC compared to those with inactive disease. Patients with active CD had significantly lower mean TAC compared to those with inactive disease but cTAC was not different between the two phases of disease activity. Patients with proctitis ha | | |
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