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Clinically proven
to reduce oxidative stress.
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Oxidative Stress and Hemochromatosis
Hereditary hemochromatosis (HH) is a hereditary disease characterized by improper processing by the body of dietary to accumulate too much iron in the tissues and eventually causing organ dysfunction. It is the main iron overload disorder. Your body derives the iron it needs from the food you eat. The individual without iron overload absorbs only as much iron as is necessary. People with HH, however, absorb too much iron and cannot rid their bodies of extra iron. Mutations of the HFE gene account for 90% of the cases. Homozygosity for the C282Y mutation is the most important one, although the heterozygosity C282Y/H63D mutations are also associated to disease (both conditions are sufficient to reach the diagnosis). Carriers of a single copy of either gene have a very slight risk of HH when other factors contribute, but are otherwise healthy.
Other genes that cause HH are the autosomal dominant SLC11A3/ferroportin 1 gene and TfR2 (transferrin receptor 2). They are much rarer than HFE-hemochromatosis. HFE-related hemochromatosis is associated with increased oxidative stress and this was reversible by normalization of the iron load by phlebotomy. Phlebotomy appears to be an effective and adequate means for reducing oxidative stress in HH patients.
About Hemochromotosis
- Hemochromatosis is a genetic disease affecting approximately 1 million Americans
- Over time if damages the joints, liver, heart, and pancreas.
- Because it has no early symptoms, hemochromatosis is often undiagnosed until serious organ damage causes other conditions or symptoms.
Risk Factors
Hereditary hemochomatosis is inherited. Risk factors for Hemochromatosis are factors that do not seem to be a direct cause of the disease, but are rather associated in some way and may include vitamin C overuse, blood transfusions, iron injections, and iron supplements.
Risk Reducers
- Close relatives of people who have hemochromatosis should have their blood tested to see if they have the disease or are carriers
- Those who have joint disease, severe and continuing fatigue, heart disease, elevated liver enzymes, impotence, and diabetes should be tested, because these conditions may result from hemochromatosis.
About Protandim®
Protandim is a powerful, patented daily supplement that dramatically boosts your body's own natural defenses against free radical damage, a leading cause of oxidative stress.
At this time, there is no evidence that Protandim can treat, cure, or prevent hemochromatosis, but we do know its positive impact on oxidative stress. Because of the known link between hemochromatosis and oxidative stress, you may want to begin by lowering your oxidative stress, which Protandim is proven to do.
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